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Pharmaceutical and Biotechnology Manufacturing in Puerto Rico

• Major pharmaceutical companies have chosen Puerto Rico as an investment destination:*
  – Merck – $300 million to produce active ingredients for VYTORIN
  – Bristol-Myers Squibb – $200 million for a fill/finish facility for biotechnology products
  – Janssen – $112 million for a fill/finish facility for biotechnology products
• The world’s leading biotechnology companies have recognized the Commonwealth’s assets, with recent investments totaling more than $3.5 billion:*
  – Amgen – $2 billion
  – Eli Lilly and Company – $850 million
  – Abbott Laboratories – $500 million
  – BD Biosciences – $52.9 million
• Fourteen of the world’s top 20 pharmaceutical companies currently have manufacturing operations on the island.**
• At present, the majority of the world’s leading pharmaceutical companies, including Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline (GSK), Johnson & Johnson, Merck & Co., Eli Lilly, Pfizer, Novartis and Wyeth – have facilities on Puerto Rico.***
• The pharmaceutical sector in Puerto Rico accounts for approximately 30% of the islands GDP, and directly employs about 26,000 people.***
• 9 of the top 10 prescription drugs sold in the United States are being made in Puerto Rico.**
• Of the top 20 main pharmaceutical products, 16 are manufactured in Puerto Rico.**
• Puerto Rico is the Caribbean’s most advanced market, worth around $1.78b in 2006.***
• Annual exports by manufacturers in Puerto Rico are worth approximately US$100bn at final retail prices; multinational sector production plants on the island produce some 36 of the 200 best-selling drugs in the U.S.***
• Industry sources claim that Puerto Rico’s biotech industry is behind only California and Massachusetts in the U.S. in terms of value.***
• The island boasts pharmaceutical industry infrastructure valued at $60bn, including 89 US FDA-approved production plants. Puerto Rico is currently the world’s fifth largest manufacturing location.***

*Puerto Rico BIOISLAND Annual Report
**ISPE Country Profile (Pharmaceutical Engineering, May/June 2005)
***Business Monitor international, Puerto Rico Pharmaceutical & Healthcare Report Q1 2007